Breast Cancer Adjuvant Therapy: Time to Consider Its Time-Dependent Effects
نویسندگان
چکیده
منابع مشابه
Time-Varying Effects of Breast Cancer Adjuvant Systemic Therapy.
BACKGROUND The benefits of breast cancer adjuvant systemic treatments are generally assumed to be proportional (or constant) over time, but limited data suggest that some treatment effects may vary with time. We therefore systematically assessed the proportional hazards assumption across all 19 breast cancer adjuvant systemic therapy trials in the National Surgical Adjuvant Breast and Bowel Pro...
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BACKGROUND A number of studies have examined time intervals between care steps in breast cancer diagnosis and treatment. The objective of this study was to document the elapsed time from first clinical or mammographic detection of breast abnormality to initiation of first adjuvant therapy in women with invasive breast cancer in Nova Scotia and to examine the effect of age, disease stage and pla...
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Time preference has a peculiar role in determining the level of economic activities. Time preferenceis the most important origin of interest rate. In this paper we study the founders and defenders'viewpoints about time preference and then we try to criticize them. It seems that discounting futureutilities is resulting from irrationality and it is ethically indefensible too. From mathematical as...
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“Deep time”—a phrase popularized by science writers such as John McPhee and Stephen J. Gould—refers to the intellectual challenge of grappling with the vast geologic and cosmologic time scale, a problem that has constrained geologists for centuries, because it is so hard to conceptualize events transpiring over billions of years. Oncologists, a group usually confronted by the pressing demands o...
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BACKGROUND High-quality care must be not only appropriate but also timely. We assessed time to initiation of adjuvant chemotherapy for breast cancer as well as factors associated with delay to help identify targets for future efforts to reduce unnecessary delays. METHODS Using data from the National Comprehensive Cancer Network (NCCN) Outcomes Database, we assessed the time from pathological ...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2011
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.2010.32.3550